Mayo Clinic Q&A podcast: Reducing rejection by reversing order of heart-liver transplant

Date :

But Dr. Sudhir Kushwaha, a Mayo Clinic cardiovascular transplant surgeon, says when a liver transplant is also involved, it sort of gives the heart protection. Now, he says, Mayo is introducing an innovative approach by transplanting the liver before the heart.

"When we looked back, at our experience with our combined heart-liver patients, we made the observation that those patients really have zero rejection," says Dr. Kushwaha. "With that in mind, we thought, well, what's going on here? There must be some biological process."

“The antibodies seem to bind in the liver in a way that doesn't harm it — the same as it does in other organs — and it really does sort of sponge up the antibodies against that specific donor,” says Dr. Richard Daly, a Mayo Clinic cardiovascular transplant surgeon.

In this Mayo Clinic Q&A podcast, Drs. Kushwaha and Daly discuss in detail this reverse transplant protocol and the research learning process of the past decade. They also discuss why some patients need this double organ transplant and they describe how the surgeries are closely choreographed with Mayo Clinic's liver transplant teams.